Question 1

Which of the following are molecular mechanisms used in epigenetic gene regulation?

Accepted Answer

A)   DNA methylation
B)   Covalent histone modification
C)   Chromatin remodeling
D)   Answers A, B, and C are correctE) C) and D)
F) All of the above

Question 2

After the paramutable allele is altered, its expression is the same or similar to the paramutagenic allele.

Accepted Answer

A) True 
 B)False  True

Question 3

In paramutation, the DNA sequence is changed temporarily

Accepted Answer

A) True 
 B)False

Question 4

If a cell is fused with another cell, which of the following would be the best example of a trans-mechanism of epigenetic control?

Accepted Answer

A)   A gene that is originally silenced in one cell but expressed in the other is silenced in the hybrid
B)   A gene that is originally silenced in one cell but expressed in the other is still expressed in the hybrid.
C)   The methylation pattern of the same gene from either cell is not altered
D)   There are no examples that could conform to a trans-mechanismE) B) and C)
F) A) and D)

Question 5

It is possible that the effects of the association of the ICR and DMR regions with the CTC factors could be distance dependent. An experimental outline could be devised where the effects of the distances of these regions could be varied and the rates of transcription could be measured. Below is a graph of some possible results. Which letter represents the most likely outcome if an increase in distance between these two regions results in a diminished effect on transcription rates.

Accepted Answer

A)   A
B)   B
C)   C
D)   DE) A) and D)
F) A) and C)

Question 6

The red1' allele is said to be paramutagenic, because it can change the expression of another allele.

Accepted Answer

A) True 
 B)False

Question 7

Most imprinted genes are silenced. What is one exception to this rule?

Accepted Answer

A)   H19
B)   Igf-2
C)   UBE3A
D)   SNRPNE) A) and B)
F) A) and C)

Question 8

What genes appear to be controlled by the Xic?

Accepted Answer

A)   Xist and Tsix
B)   Xist
C)   TsiX
D)   XicE) A) and D)
F) All of the above

Question 9

Royal jelly feed to bee larvae causes hyperexpression of DNA methyltransferase

Accepted Answer

A) True 
 B)False

Question 10

The trimethylation of lysine 27 in histone H3(H3k27) causes the repression of the FLC gene.

Accepted Answer

A) True 
 B)False

Question 11

In Arabidopsis, the FLC gene is necessary to promote flower development.

Accepted Answer

A) True 
 B)False  False

Question 12

Which of the following is part of the process of X chromosome inactivation

Accepted Answer

A)   Expression of Xist from both chromosomes at the start of the process
B)   Binding of multiple Xist transcripts to Xic on the X chromosome that will be inactivated
C)   Compaction of the active X chromosome into a Barr body
D)   Binding of Tsix transcripts to the X chromosome to be inactivated after the Xist transcripts binds to XicE) A) and D)
F) A) and C)

Question 13

In cancer cells there is typically under expression of oncogenes

Accepted Answer

A) True 
 B)False

Question 14

What is the difference between the trithorax (TrxG)  and polycomb (PcG)  complexes of proteins?

Accepted Answer

A)   TrxG proteins methylate lysine 27 on histone H3 while PcG complexes methylate lysine 4 on H3
B)   Methylation of lysine at position 4 on H3 results in silencing of gene expression
C)   TrxG complex proteins activate gene expression by methylating lysine 4 on H3, while PcG complex proteins repress gene expression by methylating lysine 27 on H3.
D)   Methylation of H3 on lysine 27 can result in activation of transcriptionE) A) and D)
F) A) and B)

Question 15

Which of the following is an example of epigenetic inheritance

Accepted Answer

A)   Expression of the Igf-2 gene based on methylation of the ICR and DMR regions
B)   Inheritance of flower color as studied by Mendel
C)   Leaf coloration based on mitochondrial inheritance
D)   Snail shell twist patternsE) A) and D)
F) None of the above

Question 16

Lamarck is remembered for his theory of inheritance which hypothesized that physical characteristics acquired during an individuals lifetime were passed onto their offspring. How does this differ from epigenetic inheritance where the diet of the mother affects coat color of the offspring?

Accepted Answer

A)   There is no difference between Lamarckian theories of inheritance and epigenetic inheritance
B)   Epigenetic changes occur on a specific gene. If the mother does not carry the gene, then coat color will not be affected by diet
C)   The change in coat color occurs in the offspring and not in the mother
D)   Answers B and C are correctE) All of the above
F) A) and B)

Question 17

How many Barr bodies would an individual with a XXY genotype possess?

Accepted Answer

A)   0
B)   1
C)   2
D)   None of the answers are correctE) A) and B)
F) All of the above B

Question 18

In maize red1' is a strongly expressed allele that is paramutable

Accepted Answer

A) True 
 B)False

Question 19

What is the molecular mechanism for imprinting a gene?

Accepted Answer

A)   Acetylation
B)   Nitration
C)   Phosphorylation
D)   MethylationE) A) and B)
F) A) and C)

Question 20

If a human cell has two Barr bodies then the genotype of the individual could be

Accepted Answer

A)   XXXY
B)   XXXXY
C)   XXY
D)   XYYE) None of the above
F) B) and C)

Exam 16: Gene Regulation in Eukaryotes Ii: Epigenetics

Which of the following are molecular mechanisms used in epigenetic gene regulation?

Correct Answer
verified

After the paramutable allele is altered, its expression is the same or similar to the paramutagenic allele.

Correct Answer
verified
True

In paramutation, the DNA sequence is changed temporarily

Correct Answer
verified

If a cell is fused with another cell, which of the following would be the best example of a trans-mechanism of epigenetic control?

Correct Answer
verified

Correct Answer
verified

The red1' allele is said to be paramutagenic, because it can change the expression of another allele.

Correct Answer
verified

Most imprinted genes are silenced. What is one exception to this rule?

Correct Answer
verified

What genes appear to be controlled by the Xic?

Correct Answer
verified

Royal jelly feed to bee larvae causes hyperexpression of DNA methyltransferase

Correct Answer
verified

The trimethylation of lysine 27 in histone H3(H3k27) causes the repression of the FLC gene.

Correct Answer
verified

In Arabidopsis, the FLC gene is necessary to promote flower development.

Correct Answer
verified
False

Which of the following is part of the process of X chromosome inactivation

Correct Answer
verified

In cancer cells there is typically under expression of oncogenes

Correct Answer
verified

What is the difference between the trithorax (TrxG) and polycomb (PcG) complexes of proteins?

Correct Answer
verified

Which of the following is an example of epigenetic inheritance

Correct Answer
verified

Lamarck is remembered for his theory of inheritance which hypothesized that physical characteristics acquired during an individuals lifetime were passed onto their offspring. How does this differ from epigenetic inheritance where the diet of the mother affects coat color of the offspring?

Correct Answer
verified

How many Barr bodies would an individual with a XXY genotype possess?

Correct Answer
verified
B

In maize red1' is a strongly expressed allele that is paramutable

Correct Answer
verified

What is the molecular mechanism for imprinting a gene?

Correct Answer
verified

If a human cell has two Barr bodies then the genotype of the individual could be

Correct Answer
verified

Exam 16: Gene Regulation in Eukaryotes Ii: Epigenetics

Which of the following are molecular mechanisms used in epigenetic gene regulation?

Correct AnswerverifiedShow Answer

After the paramutable allele is altered, its expression is the same or similar to the paramutagenic allele.

Correct AnswerverifiedTrue

In paramutation, the DNA sequence is changed temporarily

Correct AnswerverifiedShow Answer

If a cell is fused with another cell, which of the following would be the best example of a trans-mechanism of epigenetic control?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

The red1' allele is said to be paramutagenic, because it can change the expression of another allele.

Correct AnswerverifiedShow Answer

Most imprinted genes are silenced. What is one exception to this rule?

Correct AnswerverifiedShow Answer

What genes appear to be controlled by the Xic?

Correct AnswerverifiedShow Answer

Royal jelly feed to bee larvae causes hyperexpression of DNA methyltransferase

Correct AnswerverifiedShow Answer

The trimethylation of lysine 27 in histone H3(H3k27) causes the repression of the FLC gene.

Correct AnswerverifiedShow Answer

In Arabidopsis, the FLC gene is necessary to promote flower development.

Correct AnswerverifiedFalse

Which of the following is part of the process of X chromosome inactivation

Correct AnswerverifiedShow Answer

In cancer cells there is typically under expression of oncogenes

Correct AnswerverifiedShow Answer

What is the difference between the trithorax (TrxG) and polycomb (PcG) complexes of proteins?

Correct AnswerverifiedShow Answer

Which of the following is an example of epigenetic inheritance

Correct AnswerverifiedShow Answer

Lamarck is remembered for his theory of inheritance which hypothesized that physical characteristics acquired during an individuals lifetime were passed onto their offspring. How does this differ from epigenetic inheritance where the diet of the mother affects coat color of the offspring?

Correct AnswerverifiedShow Answer

How many Barr bodies would an individual with a XXY genotype possess?

Correct AnswerverifiedB

In maize red1' is a strongly expressed allele that is paramutable

Correct AnswerverifiedShow Answer

What is the molecular mechanism for imprinting a gene?

Correct AnswerverifiedShow Answer

If a human cell has two Barr bodies then the genotype of the individual could be

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified
True

Correct Answer
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Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
False

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified
B

Correct Answer
verified

Correct Answer
verified

Correct Answer
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