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The function of the viral protein coat is to


A) protect the viral genetic material.
B) aid in the transfer of the viral genetic material between host cells.
C) elicit the production of protective antibodies.
D) protect the viral genetic material and aid in the transfer of the viral genetic material between host cells.

E) C) and D)
F) None of the above

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Prions consist of proteins and have no apparent nucleic acid genome.

A) True
B) False

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Virion size ranges from


A) 1-40 nm.
B) 10-400 nm.
C) 600- 1,000 nm.
D) 1,000-10,000 nm.

E) A) and B)
F) None of the above

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Some viruses cause abnormal growth of cells rather than destruction. This is called __________.

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Which of the following is not true regarding the human hepatitis D virusoid?


A) Its genome is a circular, single-stranded RNA molecule.
B) It needs a helper virus to infect host cells.
C) It produces one protein called the delta antigen.
D) All of the statements are true.

E) A) and B)
F) A) and C)

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The simplest viruses consist of


A) RNA only.
B) Protein only.
C) RNA or DNA in a protein coat.
D) RNA or DNA in a protein coat covered with lipid envelope.
E) RNA, DNA and enzymes in a protein coat with a lipid envelope.

F) B) and E)
G) B) and D)

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A complete virus particle is called a


A) capsid.
B) nucleocapsid.
C) virion.
D) cell.

E) A) and D)
F) C) and D)

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Which of the following is not true of viruses?


A) Viruses are acellular.
B) Viruses consist of one or more molecules of DNA or RNA enclosed in a coat of protein and sometimes in other more complex layers.
C) Viruses can exist in two phases: intracellular and extracellular.
D) Viruses replicate by binary fission.

E) B) and D)
F) All of the above

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0.2 mls of a 10-4 dilution of a virus preparation yields 90 plaques. What is the number of PFU per ml in the undiluted virus preparation?


A) 9.0 ×\times 105
B) 4.5 ×\times 106
C) 4.5 ×\times 107
D) 9.0 ×\times 108

E) A) and B)
F) A) and C)

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Most enveloped viruses use the host __________ membrane as their envelope source.


A) plasma
B) nuclear
C) mitochondrial
D) none of these

E) B) and D)
F) A) and B)

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The nucleic acids carried by viruses usually consist of


A) DNA.
B) RNA.
C) either DNA or RNA.
D) both DNA and RNA simultaneously.

E) B) and C)
F) None of the above

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Nonenveloped viruses most often gain access to eukaryotic host cells by


A) fusion with the host cell plasma membrane followed by entrance of the nucleocapsid into the cytoplasm.
B) endocytosis.
C) pinocytosis.
D) nucleic acid injection through the plasma membrane.

E) All of the above
F) A) and D)

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Which of the following is not true of viroids?


A) Viroids are small circular ssRNA molecules.
B) Viroids have no protein capsids.
C) Viroid RNA does not serve as mRNA nor does it direct the synthesis of mRNA.
D) Extracellular viroids have a lipid bilayer envelope.

E) B) and C)
F) C) and D)

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Some complex viruses have icosahedral symmetry in the head region and helical symmetry in the tail. Overall, these viruses are said to have __________ symmetry.


A) bilateral
B) binal
C) complex
D) none of these

E) All of the above
F) None of the above

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The most common capsid morphologies are icosahedral and helical.

A) True
B) False

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The largest viruses known are the


A) herpesviruses.
B) hepadnaviruses.
C) adenoviruses.
D) poxviruses.

E) A) and B)
F) None of the above

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Hemagglutination is


A) the clumping together of red blood cells in the presence of a viral suspension.
B) the binding of iron in the process of a viral suspension.
C) the clumping together of infected cells in the presence of a viral suspension.
D) none of the choices

E) B) and D)
F) A) and D)

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In an enveloped virus, the part of the virus including the nucleic acid genome and the surrounding protein coat but not the envelope is called the


A) capsid.
B) nucleocapsid.
C) matrix.
D) virion.

E) All of the above
F) None of the above

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Enveloped viruses may enter their host cells by fusion of their envelope with the cytoplasmic membrane, thereby depositing their nucleocapsid within the cell.

A) True
B) False

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Viruses such as MS2 and Qß pack additional information into their genomes through the use of overlapping genes.

A) True
B) False

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